About the Company
Thermo Fisher Scientific Inc. is the world leader in serving science, with annual revenue exceeding $40 billion. Our mission is to enable our customers to make the world healthier, cleaner, and safer. Through our brands – Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Unity Lab Services, and Patheon – we offer an unmatched combination of innovative technologies, purchasing convenience, and pharmaceutical services. We help our customers accelerate research, solve complex analytical challenges, improve patient diagnostics, deliver medicines to market, and increase laboratory productivity.
Job Description
We are seeking a highly motivated and experienced Bioanalytical Chemist with a strong focus on protein and small molecule analysis to join our dynamic R&D team in West Covina, CA. In this role, you will be instrumental in developing, validating, and executing cutting-edge bioanalytical methods to support drug discovery and development programs. Your expertise will directly contribute to understanding drug pharmacokinetics, pharmacodynamics, and immunogenicity, crucial for advancing therapeutic candidates. This position offers an exciting opportunity to work with advanced instrumentation and collaborate with multidisciplinary scientific teams in a fast-paced, innovative environment.
Key Responsibilities
- Develop, optimize, and validate robust bioanalytical methods for the quantification of proteins, peptides, and small molecules in various biological matrices using techniques such as LC-MS/MS, HPLC, ELISAs, and other immunoassay platforms.
- Perform routine sample analysis, data acquisition, processing, and interpretation in accordance with GLP/GCP guidelines and internal standard operating procedures.
- Operate and maintain a variety of analytical instruments, including liquid chromatography systems (HPLC, UPLC), mass spectrometers (triple quadrupole, high-resolution MS), and automated liquid handling systems.
- Troubleshoot analytical methods and instrumentation to ensure data quality and integrity.
- Document experimental procedures, results, and conclusions in detailed laboratory notebooks and technical reports.
- Present scientific findings to internal teams and contribute to project discussions.
- Stay current with scientific literature and industry trends in bioanalytical chemistry and protein analysis.
- Ensure compliance with all safety regulations and quality assurance protocols.
Required Skills
- Ph.D. in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or a related field with 0-2 years of relevant experience, or M.S. with 3+ years, or B.S. with 5+ years of relevant experience.
- Proven expertise in developing and validating bioanalytical methods for proteins, peptides, and small molecules.
- Hands-on experience with LC-MS/MS (triple quadrupole and/or high-resolution accurate mass systems) for quantitative analysis.
- Proficiency in chromatographic techniques (HPLC, UPLC) and sample preparation methodologies.
- Experience with immunoassay techniques (e.g., ELISA, MSD, Luminex) for protein quantification and immunogenicity assessment.
- Strong understanding of GLP/GCP regulations and their application in bioanalytical laboratories.
- Excellent data analysis, interpretation, and problem-solving skills.
- Strong written and verbal communication skills.
Preferred Qualifications
- Experience in a pharmaceutical or biotechnology industry setting.
- Familiarity with regulatory guidelines for bioanalytical method validation (e.g., FDA, EMA).
- Experience with LIMS, electronic lab notebooks (ELN), and statistical software packages.
- Knowledge of protein purification and characterization techniques.
- Prior experience working with automated liquid handling systems.
Perks & Benefits
- Comprehensive Medical, Dental, and Vision insurance plans.
- 401(k) retirement plan with company match.
- Paid time off (PTO) and company-paid holidays.
- Opportunities for professional development and career advancement.
- Tuition reimbursement program.
- Employee assistance program.
- Life and disability insurance.
How to Apply
If you are interested in this position, please click the "Apply Now" button below. To ensure your application is properly considered, please prepare the following:
- An up-to-date Resume or CV
- A brief cover letter summarizing your experience and motivation
Applications are reviewed on a rolling basis. Only shortlisted candidates will be contacted for an interview.
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